Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

• Nanotechnology, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu 603203, India 10.3762/bjnano.11.41 Abstract Multilayer capsules have been of great interest for scientists and medical communities in multidisciplinary fields of research, such as drug delivery, sensing, biomedicine

• potential applications. Keywords: drug delivery; functionalization; multilayer capsules; synthesis; weak polyelectrolytes; Review Introduction In the last few decades, micrometer and nanometer-sized capsules made of polyelectrolytes (PEs) have been the subject of intensive research because of their

• or sustained manner. As weak PEs are in ionized form only in a certain range of pH or ionic strength [6], the open and closed state of multilayer capsules could be easily controlled by varying pH or ionic strength, a concept that led to widespread use in in vivo applications [7]. Much progress has